p16INK4a is a prognostic marker in resected ductal pancreatic cancer: an analysis of p16INK4a, p53, MDM2, an Rb.

@article{Gerdes2002p16INK4aIA,
  title={p16INK4a is a prognostic marker in resected ductal pancreatic cancer: an analysis of p16INK4a, p53, MDM2, an Rb.},
  author={Berthold Gerdes and Annette Ramaswamy and Andreas Ziegler and Sven Arke Lang and Michael Kersting and Renate Baumann and Anja Wild and Roland Moll and Matthias Rothmund and Detlef Klaus Bartsch},
  journal={Annals of surgery},
  year={2002},
  volume={235 1},
  pages={51-9}
}
OBJECTIVE To identify the prognostic relevance of the G1/S cell cycle regulator genes p16INK4a, p53, MDM2, and Rb in patients with resected ductal pancreatic cancer (PC). SUMMARY BACKGROUND DATA The tumor suppressor genes p16INK4a, p53, and Rb are altered in PC in 27% to 95%, 40% to 70%, and 5%, respectively. The role of MDM2 is not clearly defined in PC. The prognostic value of these cell cycle regulators has not been clarified. METHODS Sixty-two patients with PC with complete follow-up… CONTINUE READING

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