p16INK4A is a robust in vivo biomarker of cellular aging in human skin.

@article{Ressler2006p16INK4AIA,
  title={p16INK4A is a robust in vivo biomarker of cellular aging in human skin.},
  author={Sigrun Ressler and Jirina Bartkova and Harald Niederegger and Jiri Bartek and Karin Scharffetter-Kochanek and Pidder Jansen-Duerr and Meinhard Wlaschek},
  journal={Aging cell},
  year={2006},
  volume={5 5},
  pages={379-89}
}
The cell-cycle regulating gene, p16INK4A, encoding an inhibitor of cyclin-dependent kinases 4 and 6, is considered to play an important role in cellular aging and in premature senescence. Although there is an age-dependent increase of p16INK4A expression in human fibroblast senescence in vitro, no data are available regarding the age dependency of p16INK4A in vivo. To determine whether p16INK4A expression in human skin correlates with donor age, p16INK4A expression was analyzed by… CONTINUE READING

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