• DOI:10.1016/J.HUMPATH.2004.09.004
Corpus ID: 2120159

p16INK4A expression as biomarker for HPV 16-related vulvar neoplasias.

@article{Riethdorf2004p16INK4AEA,
  title={p16INK4A expression as biomarker for HPV 16-related vulvar neoplasias.},
  author={S. Riethdorf and E. Neffen and A. Cviko and T. Loening and C. Crum and L. Riethdorf},
  journal={Human pathology},
  year={2004},
  volume={35 12},
  pages={
          1477-83
        }
}

S. Riethdorf, E. Neffen, +3 authors L. Riethdorf

Published 2004

Biology, Medicine

Human pathology

Up-regulation of p16INK4A is associated with high-risk human papillomavirus (HPV) in preinvasive and invasive cervical neoplasia. However, its expression in vulvar carcinomas, which have a diverse pathogenesis, has not been extensively studied. One hundred seventy-seven vulvar intraepithelial neoplasms (VIN), squamous cell carcinomas (SCC), and benign squamous epithelia were analyzed for p16 expression. RNA/RNA in situ hybridization was used to detect HPV 16 E6/E7 transcripts in 112. Ninety… CONTINUE READING

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