p16INK4A expression as biomarker for HPV 16-related vulvar neoplasias.

  title={p16INK4A expression as biomarker for HPV 16-related vulvar neoplasias.},
  author={S. Riethdorf and E. Neffen and A. Cviko and T. Loening and C. Crum and L. Riethdorf},
  journal={Human pathology},
  volume={35 12},
  • S. Riethdorf, E. Neffen, +3 authors L. Riethdorf
  • Published 2004
  • Biology, Medicine
  • Human pathology
  • Up-regulation of p16INK4A is associated with high-risk human papillomavirus (HPV) in preinvasive and invasive cervical neoplasia. However, its expression in vulvar carcinomas, which have a diverse pathogenesis, has not been extensively studied. One hundred seventy-seven vulvar intraepithelial neoplasms (VIN), squamous cell carcinomas (SCC), and benign squamous epithelia were analyzed for p16 expression. RNA/RNA in situ hybridization was used to detect HPV 16 E6/E7 transcripts in 112. Ninety… CONTINUE READING
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