p16INK4A Represses the paracrine tumor-promoting effects of breast stromal fibroblasts

Abstract

Cancer-associated fibroblasts (CAFs), the most abundant and probably the most active cellular component of breast cancer-associated stroma, promote carcinogenesis through paracrine effects; however, the molecular basis remains elusive. We have shown here that p16INK4A expression is reduced in 83% CAFs as compared with their normal adjacent counterparts… (More)
DOI: 10.1038/onc.2012.270

7 Figures and Tables

Topics

  • Presentations referencing similar topics