p16 protein expression and human papillomavirus status as prognostic biomarkers of nonoropharyngeal head and neck squamous cell carcinoma.

@article{Chung2014p16PE,
  title={p16 protein expression and human papillomavirus status as prognostic biomarkers of nonoropharyngeal head and neck squamous cell carcinoma.},
  author={Christine H. Chung and Qiang Zhang and Christina S. Kong and Jonathan Harris and Elana J. Fertig and Paul M. Harari and Dian Wang and Kevin P Redmond and George Shenouda and Andy M. Trotti and David Raben and Maura L. Gillison and Richard C. K. Jordan and Quynh-Thu Le},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2014},
  volume={32 35},
  pages={3930-8}
}
PURPOSE Although p16 protein expression, a surrogate marker of oncogenic human papillomavirus (HPV) infection, is recognized as a prognostic marker in oropharyngeal squamous cell carcinoma (OPSCC), its prevalence and significance have not been well established in cancer of the oral cavity, hypopharynx, or larynx, collectively referred as non-OPSCC, where HPV infection is less common than in the oropharynx. PATIENTS AND METHODS p16 expression and high-risk HPV status in non-OPSCCs from RTOG… CONTINUE READING
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