p16 protein expression and human papillomavirus status as prognostic biomarkers of nonoropharyngeal head and neck squamous cell carcinoma.

@article{Chung2014p16PE,
  title={p16 protein expression and human papillomavirus status as prognostic biomarkers of nonoropharyngeal head and neck squamous cell carcinoma.},
  author={Christine H. Chung and Qiang Zhang and Christina S. Kong and Jonathan Y Harris and Elana J. Fertig and Paul M. Harari and Dian Wang and Kevin P. Redmond and George Shenouda and Andy M. Trotti and David Raben and Maura L. Gillison and Richard C K Jordan and Quynh-Thu Le},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2014},
  volume={32 35},
  pages={
          3930-8
        }
}
PURPOSE Although p16 protein expression, a surrogate marker of oncogenic human papillomavirus (HPV) infection, is recognized as a prognostic marker in oropharyngeal squamous cell carcinoma (OPSCC), its prevalence and significance have not been well established in cancer of the oral cavity, hypopharynx, or larynx, collectively referred as non-OPSCC, where HPV infection is less common than in the oropharynx. PATIENTS AND METHODS p16 expression and high-risk HPV status in non-OPSCCs from RTOG… CONTINUE READING
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