p16 gene homozygous deletions in acute lymphoblastic leukemia.

@article{Quesnel1995p16GH,
  title={p16 gene homozygous deletions in acute lymphoblastic leukemia.},
  author={Bruno Quesnel and Claude Joseph Preudhomme and Nathalie Philippe and Mickael Vanrumbeke and Isabelle Dervite and Jean Luc Lai and Francis Bauters and {\'E}ric Wattel and Pierre Fenaux},
  journal={Blood},
  year={1995},
  volume={85 3},
  pages={
          657-63
        }
}
The p16 protein is a cyclin inhibitor encoded by a gene located in 9p21, which may have antioncogenic properties, and is inactivated by homozygous p16 gene deletion or, less often, point mutation in several types of solid tumors often associated to cytogenetic evidence of 9p21 deletion. We looked for homozygous deletion and point mutation of the p16 gene in acute lymphoblastic leukemia (ALL), where 9p21 deletion or rearrangement are also nonrandom cytogenetic findings. Other hematologic… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 34 CITATIONS

Similar Papers

Loading similar papers…