p16 as a diagnostic marker of cervical neoplasia: a tissue microarray study of 796 archival specimens

@article{Lesnikova2009p16AA,
  title={p16 as a diagnostic marker of cervical neoplasia: a tissue microarray study of 796 archival specimens},
  author={Iana Lesnikova and Marianne Lidang and Stephen Jacques Hamilton-Dutoit and J\orn E. Koch},
  journal={Diagnostic Pathology},
  year={2009},
  volume={4},
  pages={22 - 22}
}
BACKGROUND To evaluate the usefulness of this biomarker in the diagnosis of cases of cervical neoplasia we studied the immunohistochemical expression of p16INK4a in a large series of archival cervical biopsies arranged into tissue microarray format. METHODS TMAs were constructed with tissue cores from archival formalin fixed, paraffin-embedded donor tissues from 796 patients, and included cases of cervical intraepithelial neoplasia (CIN)1 (n = 249), CIN2 (n = 233), CIN3 (n = 181), and… CONTINUE READING