p16 Inactivation in pancreatic intraepithelial neoplasias (PanINs) arising in patients with chronic pancreatitis.

@article{Rosty2003p16II,
  title={p16 Inactivation in pancreatic intraepithelial neoplasias (PanINs) arising in patients with chronic pancreatitis.},
  author={Christophe Rosty and Joseph Geradts and Norihiro Sato and Robb E. Wilentz and Helen Roberts and Taylor A. Sohn and John L. Cameron and Charles J Yeo and Ralph H. Hruban and Michael Goggins},
  journal={The American journal of surgical pathology},
  year={2003},
  volume={27 12},
  pages={1495-501}
}
Patients with long-standing chronic pancreatitis are thought to be at increased risk of developing pancreatic ductal adenocarcinoma, but the mechanism for this increased risk is unknown. Since increasing evidence supports the notion that infiltrating pancreatic ductal adenocarcinomas arise from pancreatic intraepithelial lesions (PanINs), we sought to determine if patients with chronic pancreatitis harbor PanINs with alterations in tumor suppressor genes that are associated with infiltrating… CONTINUE READING