p16 Improves interobserver agreement in diagnosis of anal intraepithelial neoplasia.

@article{Bean2009p16II,
  title={p16 Improves interobserver agreement in diagnosis of anal intraepithelial neoplasia.},
  author={Sarah M. Bean and Regina S Meara and Robin T. Vollmer and Michael G. Conner and David R. Crowe and Lea Novak and Isam Eldin Eltoum and Stanley J. Robboy and David C. Chhieng},
  journal={Journal of lower genital tract disease},
  year={2009},
  volume={13 3},
  pages={145-53}
}
OBJECTIVES Evaluation of anal intraepithelial neoplasia (AIN) is subjective. Previous studies have shown p16 and Ki-67 expressions to correlate with AIN grade. Biomarkers like p16 and Ki-67 may improve interobserver agreement. The objectives were (1) to determine the extent of interobserver agreement in evaluating AIN on routine hematoxylin and eosin (H&E) sections and (2) to test whether p16 and/or Ki-67 staining improve interobserver diagnostic agreement. MATERIALS AND METHODS Seventy-seven… CONTINUE READING

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