p16 FISH Deletion in Surface Epithelial Mesothelial Proliferations Is Predictive of Underlying Invasive Mesothelioma

@article{Hwang2014p16FD,
  title={p16 FISH Deletion in Surface Epithelial Mesothelial Proliferations Is Predictive of Underlying Invasive Mesothelioma},
  author={Harry C. Hwang and Christopher H Tse and St{\'e}phanie Rodriguez and Allen M. Gown and Andrew Churg},
  journal={The American Journal of Surgical Pathology},
  year={2014},
  volume={38},
  pages={681–688}
}
An atypical mesothelial proliferation along the pleural or peritoneal surface without evidence of invasive tumor poses a diagnostic challenge. Homozygous deletion of p16 (CDKN2A) by fluorescence in situ hybridization (FISH) has been shown to be a good marker of malignancy in mesothelial proliferations, but correlations of p16 status between atypical surface proliferations and underlying mesothelioma have not been described. We used p16 FISH to investigate 11 pleural and 7 peritoneal… Expand
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In cases with clinical and radiologic evidence of a diffuse pleural tumor, detection of p16 deletion in cytologic smear samples may permit MPM diagnosis without additional tissue examination, however, the absence of p 16 deletion in centrifugal smear samples does not preclude MPM. Expand
Loss of BAP1 Expression in Atypical Mesothelial Proliferations Helps to Predict Malignant Mesothelioma
TLDR
Loss of BAP1 expression in atypical mesothelial proliferation helps to predict malignant mesothelioma and is a useful adjunct test in these cases, while homozygous deletion of CDKN2A in mesotheric cell proliferations did not prove to be useful to predict MM. Expand
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TLDR
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TLDR
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TLDR
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BAP1 (BRCA1-associated protein 1) is a highly specific marker for differentiating mesothelioma from reactive mesothelial proliferations
TLDR
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Sarcomatoid Mesothelioma: A CDKN2A molecular analysis of 53 cases with immunohistochemical correlation with BAP1.
TLDR
The findings showed that even though the use of BAP1 and p16 are important tools in the diagnosis of mesothelioma, a proportion of cases still remains negative with approximately 30 % of the cases in which the concordance of B AP1 loss and p 16 homozygous deletion will not be present. Expand
Utility of BAP1 Immunohistochemistry and p16 (CDKN2A) FISH in the Diagnosis of Malignant Mesothelioma in Effusion Cytology Specimens
TLDR
Both BAP1 immunohistochemistry and p16 FISH analysis provide reliable markers of mesothelial malignancy in effusion cytology specimens, especially where the atypical mesothelioma proliferation is well sampled. Expand
Use of p16 FISH for differential diagnosis of mesothelioma in smear preparations
TLDR
It was shown that the p16 deletion status of MPM cells in pleural effusions reflected that of the underlying invasive MPM tissues, indicating the usefulness of p16 FISH in effusion smear cytology for MPM diagnosis, and proposed to perform p 16 FISH as often as possible for differentiating MPM from RMC. Expand
The pathologists and team at PhenoPath
A variety of immunohistochemical (IHC) stains have been proposed to mark either benign or malignant mesothelial proliferations. Loss of the p16 tumor suppressor (CDKN2A), through homozygous deletionsExpand
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