p16(INK4a) overexpression predicts translational active human papillomavirus infection in tonsillar cancer.

@article{Hoffmann2010p16INK4aOP,
  title={p16(INK4a) overexpression predicts translational active human papillomavirus infection in tonsillar cancer.},
  author={Markus H Hoffmann and Anna Sophie Ihloff and Tibor Goeroegh and Jan Bernd Weise and Asita Fazel and Matthias Krams and Werner Rittgen and E. Volterra Schwarz and T. H. Kahn},
  journal={International journal of cancer},
  year={2010},
  volume={127 7},
  pages={1595-602}
}
The causal role of human papillomaviruses (HPV) in squamous cell carcinogenesis of tonsillar cancers (TSCC) depends on the activity of the viral oncoproteins E6 and E7, leading to inactivation of the cellular tumor suppressor p53 and the retinoblastoma gene product pRb. Because of the negative feedback mechanisms, the pRb inactivation causes an increase of the inhibitor of the cyclin-dependent kinases p16(INK4a). In 39 TSCC specimens, genotyping based on the amplification of HPV DNA was carried… CONTINUE READING

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