p16(INK4a) is superior to high-risk human papillomavirus testing in cervical cytology for the prediction of underlying high-grade dysplasia.

@article{Samarawardana2010p16INK4aIS,
  title={p16(INK4a) is superior to high-risk human papillomavirus testing in cervical cytology for the prediction of underlying high-grade dysplasia.},
  author={Panduka Samarawardana and Donna L. Dehn and Meenakshi Singh and Douglas Franquemont and Chesney Thompson and Loretta Gaido and Kathleen C. Torkko and Petra Homer and Stephanie Burke and Matthew A. Titmus and Vipul R. Nayi and Kenneth Shroyer},
  journal={Cancer cytopathology},
  year={2010},
  volume={118 3},
  pages={
          146-56
        }
}
BACKGROUND The primary goal of this study was to compare the clinical performance of an optimized and rigorously controlled immunocytochemical (ICC) assay for p16(INK4a) to high-risk (HR) human papillomavirus (HPV) detection by polymerase chain reaction (PCR) as diagnostic adjuncts for cytology specimens from colposcopy patients. METHODS : The study included 403 cervical cytology specimens collected within 3 months of colposcopy. The colposcopic impression and cervical biopsy diagnosis served… CONTINUE READING

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