p16(INK4a) is superior to high-risk human papillomavirus testing in cervical cytology for the prediction of underlying high-grade dysplasia.

@article{Samarawardana2010p16INK4aIS,
  title={p16(INK4a) is superior to high-risk human papillomavirus testing in cervical cytology for the prediction of underlying high-grade dysplasia.},
  author={Panduka Samarawardana and Donna L Dehn and Meenakshi Singh and Douglas Franquemont and Chesney Thompson and Loretta Gaido and Kathleen C. Torkko and Petra Homer and Stephanie C Burke and Matthew A. Titmus and Vipul R. Nayi and Kenneth R. Shroyer},
  journal={Cancer cytopathology},
  year={2010},
  volume={118 3},
  pages={146-56}
}
BACKGROUND The primary goal of this study was to compare the clinical performance of an optimized and rigorously controlled immunocytochemical (ICC) assay for p16(INK4a) to high-risk (HR) human papillomavirus (HPV) detection by polymerase chain reaction (PCR) as diagnostic adjuncts for cytology specimens from colposcopy patients. METHODS : The study included 403 cervical cytology specimens collected within 3 months of colposcopy. The colposcopic impression and cervical biopsy diagnosis served… CONTINUE READING

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