p16(INK4a) immunostaining in cytological and histological specimens from the uterine cervix: a systematic review and meta-analysis.

@article{Tsoumpou2009p16INK4aII,
  title={p16(INK4a) immunostaining in cytological and histological specimens from the uterine cervix: a systematic review and meta-analysis.},
  author={Ioanna Tsoumpou and Marc Arbyn and Maria Kyrgiou and Nicolas Wentzensen and George Koliopoulos and Pierre Leonard Martin-Hirsch and Vassiliki D. Malamou-Mitsi and Evangelos Paraskevaidis},
  journal={Cancer treatment reviews},
  year={2009},
  volume={35 3},
  pages={210-20}
}
BACKGROUND P16(INK4a) is a biomarker for transforming HPV infections that could act as an adjunct to current cytological and histological assessment of cervical smears and biopsies, allowing the identification of those women with ambiguous results that require referral to colposcopy and potentially treatment. MATERIAL AND METHODS We conducted a systematic review of all studies that evaluated the use of p16(INK4a) in cytological or histological specimens from the uterine cervix. We also… CONTINUE READING