p16(INK4A) expression is related to grade of cin and high-risk human papillomavirus but does not predict virus clearance after conization or disease outcome.

@article{Branca2004p16INK4AEI,
  title={p16(INK4A) expression is related to grade of cin and high-risk human papillomavirus but does not predict virus clearance after conization or disease outcome.},
  author={Margherita Branca and Marco Ciotti and Donatella Santini and Lu{\'i}gi Di Bonito and Colomba Giorgi and Arrigo Benedetto and Pierpaulo Paba and Cartesio Favalli and Silvano Costa and Alberto Agarossi and Mauro Alderisio and Kari Juhani Syrj{\"a}nen},
  journal={International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists},
  year={2004},
  volume={23 4},
  pages={354-65}
}
The role of p16(INK4A) as a marker of HR-HPV and in the diagnosis of CIN has been well established, but its predictive value in the clearance of the virus after CIN treatment and its use as a prognostic marker of cervical cancer has not been studied. A series of 302 archival samples, including 150 squamous cell carcinomas (SCCs) and 152 CIN lesions, were subjected to immunohistochemical staining for p16(INK4A) and HPV testing using PCR with three primer sets (MY09/11, GP5/GP6, SPF). Follow-up… CONTINUE READING

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