p16(INK4) is inactivated by extensive CpG methylation in human hepatocellular carcinoma.

@article{Matsuda1999p16INK4II,
  title={p16(INK4) is inactivated by extensive CpG methylation in human hepatocellular carcinoma.},
  author={Yoshiro Matsuda and Takafumi Ichida and Jun Matsuzawa and Kazuhito Sugimura and Hitoshi Asakura},
  journal={Gastroenterology},
  year={1999},
  volume={116 2},
  pages={394-400}
}
BACKGROUND & AIMS The molecular status of the p16(INK4) tumor-suppressor gene has not been fully elucidated in hepatocellular carcinoma. The aim of this study was to clarify the mechanism that gives rise to inactivation of p16(INK4) in hepatocellular carcinoma. METHODS The status of p16(INK4) was evaluated in 60 hepatocellular carcinomas by immunohistochemical staining, differential polymerase chain reaction, single-strand conformational polymorphism, methylation-specific polymerase chain… CONTINUE READING
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