p15RS Attenuates Wnt/β-Catenin Signaling by Disrupting β-Catenin·TCF4 Interaction*

@article{Wu2010p15RSAW,
  title={p15RS Attenuates Wnt/$\beta$-Catenin Signaling by Disrupting $\beta$-Catenin·TCF4 Interaction*},
  author={Y. Wu and Yanquan Zhang and Haiwei Zhang and Xi Yang and Yinyin Wang and F. Ren and Huitu Liu and Yonggong Zhai and B. Jia and Jun Yu and Z. Chang},
  journal={The Journal of Biological Chemistry},
  year={2010},
  volume={285},
  pages={34621 - 34631}
}
The formation of a β-catenin·TCF4 complex in the nucleus of cells is well known as a prerequisite for the transcription of Wnt target genes. Although many co-factors have been identified to regulate the activity of the β-catenin·TCF4 complex, it remains unclear how the complex association is negatively regulated. In this study, we report that p15RS, a negative regulator of the cell cycle, blocks β-catenin·TCF4 complex formation and inhibits Wnt signaling. We observed that p15RS interacts with… Expand
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TLDR
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Background: p15RS/RPRD1A inhibits Wnt/β-catenin signaling by recruiting HDAC2. Results: p15RS interacts with HDAC2 and enhances the occupancy of HDAC2 to promoters of Wnt-targeted genes, keepingExpand
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  • Biology, Medicine
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  • 2012
TLDR
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Dickkopf 4 (DKK4) acts on Wnt/β-catenin pathway by influencing β-catenin in hepatocellular carcinoma
TLDR
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Dimerization of p15RS mediated by a leucine zipper–like motif is critical for its inhibitory role on Wnt signaling
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  • Chemistry, Medicine
  • The Journal of Biological Chemistry
  • 2018
TLDR
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