p15RS/RPRD1A (p15INK4b-related Sequence/Regulation of Nuclear Pre-mRNA Domain-containing Protein 1A) Interacts with HDAC2 in Inhibition of the Wnt/β-Catenin Signaling Pathway*

@article{Liu2015p15RSRPRD1AS,
  title={p15RS/RPRD1A (p15INK4b-related Sequence/Regulation of Nuclear Pre-mRNA Domain-containing Protein 1A) Interacts with HDAC2 in Inhibition of the Wnt/$\beta$-Catenin Signaling Pathway*},
  author={Chunxiao Liu and Yanquan Zhang and Jun Li and Yinyin Wang and F. Ren and Yifan Zhou and Yinyuan Wu and Yarui Feng and Yu Zhou and Fuqin Su and B. Jia and Dong Wang and Zhijie Chang},
  journal={The Journal of Biological Chemistry},
  year={2015},
  volume={290},
  pages={9701 - 9713}
}
Background: p15RS/RPRD1A inhibits Wnt/β-catenin signaling by recruiting HDAC2. Results: p15RS interacts with HDAC2 and enhances the occupancy of HDAC2 to promoters of Wnt-targeted genes, keeping histone3 in a deacetylated state. Conclusion: p15RS cooperates with HADC2 in the inhibition of Wnt/β-catenin signaling. Significance: p15RS/HDAC2 is a novel co-repressor in the regulation of Wnt/β-catenin signaling. We previously reported that p15RS (p15INK4b-related sequence), a regulation of nuclear… Expand
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