p14ARF promoter hypermethylation in plasma DNA as an indicator of disease recurrence in bladder cancer patients.

PURPOSE Several genes are reported to be implicated in bladder carcinogenesis, including p53, p16INK4a, pRb, erbB-2, Cyclin D1, H-ras, EGFR, and c-myc. Gene alterations in plasma DNA identical to those observed within the tumor have been detected in various types of neoplasia. EXPERIMENTAL DESIGN We analyzed loss of heterozygosity in six microsatellite… CONTINUE READING