p14ARF links the tumour suppressors RB and p53

  title={p14ARF links the tumour suppressors RB and p53},
  author={S. Bates and A. C. Phillips and P. A. Clark and F. Stott and G. Peters and R. Ludwig and K. Vousden},
  • S. Bates, A. C. Phillips, +4 authors K. Vousden
  • Published 1998
  • Medicine, Biology
  • Nature
  • Most human cancers show perturbation of growth regulation mediated by the tumour-suppressor proteins retinoblastoma (RB) and p53 (ref. 1), indicating that loss of both pathways is necessary for tumour development. Loss of RB function leads to abnormal proliferation related to the deregulation of the E2F transcription factors, but also results in the activation of p53, which suppresses cell growth. Here we show that E2F-1 directly activates expression of the human tumour-suppressor protein… CONTINUE READING
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