p14ARF links the tumour suppressors RB and p53

@article{Bates1998p14ARFLT,
  title={p14ARF links the tumour suppressors RB and p53},
  author={Stewart Bates and Andrew C. Phillips and Paula A. Clark and Francesca J. Stott and Gordon G. Peters and Robert L. Ludwig and Karen H. Vousden},
  journal={Nature},
  year={1998},
  volume={395},
  pages={124-125}
}
Most human cancers show perturbation of growth regulation mediated by the tumour-suppressor proteins retinoblastoma (RB) and p53 (ref. 1), indicating that loss of both pathways is necessary for tumour development. Loss of RB function leads to abnormal proliferation related to the deregulation of the E2F transcription factors, but also results in the activation of p53, which suppresses cell growth. Here we show that E2F-1 directly activates expression of the human tumour-suppressor protein… 
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References

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens
TLDR
The effects of the Rb-deficient state on the development of the ocular lens are described and it is demonstrated that loss of Rb function is associated with unchecked proliferation, impaired expression of differentiation markers, and inappropriate apoptosis in lens fibre cells.