p14ARF genetic polymorphisms and susceptibility to second primary malignancy in patients with index squamous cell carcinoma of the head and neck.

@article{Zhang2011p14ARFGP,
  title={p14ARF genetic polymorphisms and susceptibility to second primary malignancy in patients with index squamous cell carcinoma of the head and neck.},
  author={Yang Zhang and Erich M Sturgis and Mark E Zafereo and Qingyi Wei and Guojun Li},
  journal={Cancer},
  year={2011},
  volume={117 6},
  pages={1227-35}
}
BACKGROUND p14(ARF) , an alternate reading frame (ARF) product of the cyclin-dependent kinase inhibitor 2A locus, plays a critical role in crosstalk between the tumor protein 53 (p53) and retinoblastoma (Rb) pathways and in cellular anticancer mechanisms. Therefore, the authors of this report investigated the association between single nucleotide polymorphisms (SNPs) of the p14(ARF) gene and the risk of developing a second primary malignancy (SPM) after an index squamous cell carcinoma of the… CONTINUE READING
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