p130 mediates TGF-beta-induced cell-cycle arrest in Rb mutant HT-3 cells.

@article{Choi2002p130MT,
  title={p130 mediates TGF-beta-induced cell-cycle arrest in Rb mutant HT-3 cells.},
  author={Hyun Ho Choi and Hyun Soon Jong and Sang Hyun Song and Tae You Kim and Noe Kyeong Kim and Yung Jue Bang},
  journal={Gynecologic oncology},
  year={2002},
  volume={86 2},
  pages={184-9}
}
OBJECTIVE The retinoblastoma proteins include Rb and the functionally and structurally related proteins p107 and p130. It has been reported that HT-3 cells are sensitive to TGF-beta growth inhibition, despite the Rb mutation. The purpose of this study was to elucidate the growth-inhibitory mechanism of TGF-beta in Rb mutant HT-3 cells. METHODS Growth inhibition by TGF-beta in cervical carcinoma cell lines was evaluated by counting cell numbers. Cell-cycle distribution was determined by… CONTINUE READING