p130/p107/p105Rb-dependent transcriptional repression during DNA-damage-induced cell-cycle exit at G2.

@article{Jackson2005p130p107p105RbdependentTR,
  title={p130/p107/p105Rb-dependent transcriptional repression during DNA-damage-induced cell-cycle exit at G2.},
  author={Mark W Jackson and Mukesh Kumar Agarwal and Jinbo Yang and Patrick Bruss and Takeshi Uchiumi and M. L. Agarwal and George R Stark and William R Taylor},
  journal={Journal of cell science},
  year={2005},
  volume={118 Pt 9},
  pages={
          1821-32
        }
}
The progression of normal cells from G2 into mitosis is stably blocked when their DNA is damaged. Tumor cells lacking p53 arrest only transiently in G2, but eventually enter mitosis. We show that an important component of the stable G2 arrest in normal cells is the transcriptional repression of more than 20 genes encoding proteins needed to enter into and progress through mitosis. Studies from a number of labs including our own have shown that, by inducing p53 and p21/WAF1, DNA damage can… CONTINUE READING
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