p12CDK2-AP1 mediates DNA damage responses induced by cisplatin

@article{Kim2005p12CDK2AP1MD,
  title={p12CDK2-AP1 mediates DNA damage responses induced by cisplatin},
  author={Yong geun Kim and Jim J. McBride and Rong Cheng Zhang and Xiaofeng Zhou and David Wong},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={407-418}
}
We examined the biological role of p12CDK2-AP1 in cisplatin-mediated responses by using murine ES p12CDK2-AP1 knockout clones generated by a targeted disruption of murine p12CDK2-AP1. Homozygous knockout clones showed an increased cellular proliferation along with an increase in S and a decrease in G2/M phase populations. Interestingly, ES p12CDK2-AP1 knockout clones showed a resistance to cisplatin treatment along with an increased DNA repair activity assessed by host cell reactivation assay… CONTINUE READING
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