p120 catenin is required for morphogenetic movements involved in the formation of the eyes and the craniofacial skeleton in Xenopus.

@article{Ciesiolka2004p120CI,
  title={p120 catenin is required for morphogenetic movements involved in the formation of the eyes and the craniofacial skeleton in Xenopus.},
  author={Malgorzata Ciesiolka and Mieke Delvaeye and Griet Van Imschoot and Veerle Verschuere and P. D. Mccrea and Frans van Roy and Kris Vleminckx},
  journal={Journal of cell science},
  year={2004},
  volume={117 Pt 18},
  pages={
          4325-39
        }
}
During Xenopus development, p120 transcripts are enriched in highly morphogenetic tissues. We addressed the developmental function of p120 by knockdown experiments and by expressing E-cadherin mutants unable to bind p120. This resulted in defective eye formation and provoked malformations in the craniofacial cartilage structures, derivatives of the cranial neural crest cells. Closer inspection showed that p120 depletion impaired evagination of the optic vesicles and migration of cranial neural… CONTINUE READING

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Inhibition of RhoA by p120 catenin

  • Nature Cell Biology
  • 2000
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