p120 Catenin-Mediated Stabilization of E-Cadherin Is Essential for Primitive Endoderm Specification

Abstract

E-cadherin-mediated cell-cell adhesion is critical for naive pluripotency of cultured mouse embryonic stem cells (mESCs). E-cadherin-depleted mESC fail to downregulate their pluripotency program and are unable to initiate lineage commitment. To further explore the roles of cell adhesion molecules during mESC differentiation, we focused on p120 catenin… (More)
DOI: 10.1371/journal.pgen.1006243

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@inproceedings{Pieters2016p120CS, title={p120 Catenin-Mediated Stabilization of E-Cadherin Is Essential for Primitive Endoderm Specification}, author={Tim Pieters and Steven Goossens and Lieven Haenebalcke and Vanessa Andries and Agata Stryjewska and Riet de Rycke and Kelly Lemeire and Tino Hochepied and Danny Huylebroeck and Geert Berx and Marc P Stemmler and Dagmar Wirth and Jody J. Haigh and Jolanda van Hengel and Frans van Roy}, booktitle={PLoS genetics}, year={2016} }