p110-related PI 3-kinases regulate phagosome-phagosome fusion and phagosomal pH through a PKB/Akt dependent pathway in Dictyostelium.

@article{Rupper2001p110relatedP3,
  title={p110-related PI 3-kinases regulate phagosome-phagosome fusion and phagosomal pH through a PKB/Akt dependent pathway in Dictyostelium.},
  author={Adam C Rupper and J M Rodriguez-Paris and Bryon D. Grove and James A. Cardelli},
  journal={Journal of cell science},
  year={2001},
  volume={114 Pt 7},
  pages={1283-95}
}
The Dictyostelium p110-related PI 3-kinases, PIK1 and PIK2, regulate the endosomal pathway and the actin cytoskeleton, but do not significantly regulate internalization of particles in D. discoideum. Bacteria internalized into delta ddpik1/ddpik2 cells or cells treated with PI 3-kinase inhibitors remained intact as single particles in phagosomes with… CONTINUE READING