p11 is up-regulated in the forebrain of stressed rats by glucocorticoid acting via two specific glucocorticoid response elements in the p11 promoter.

@article{Zhang2008p11IU,
  title={p11 is up-regulated in the forebrain of stressed rats by glucocorticoid acting via two specific glucocorticoid response elements in the p11 promoter.},
  author={Lei Zhang and Hongxin Li and T P Su and Jeffery L. Barker and Dragan Maric and Carol S. Fullerton and Maree J. Webster and Christopher J Hough and Xiao xia Li and Robert Ursano},
  journal={Neuroscience},
  year={2008},
  volume={153 4},
  pages={1126-34}
}
Posttraumatic stress disorder (PTSD) is one of the most common psychiatric disorders. Despite the extensive study of the neurobiological correlates of this disorder, the underlying mechanisms of PTSD are still poorly understood. Recently, a study demonstrated that dexamethasone (Dex), a synthetic glucocorticoid, can up-regulate p11, known as S100A10-protein which is down-regulated in patients with depression, (Yao et al., 1999; Huang et al., 2003) a common comorbid disorder in PTSD. These… CONTINUE READING

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