p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction.

@article{Mercurio1993p105AP,
  title={p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction.},
  author={Frank Mercurio and Joseph A. DiDonato and Caridad Rosette and Michael Karin},
  journal={Genes & development},
  year={1993},
  volume={7 4},
  pages={705-18}
}
The Rel/NF-kappa B family of transcription factors is composed of two distinct subgroups, proteins that undergo proteolytic processing and contain SWI6/ankyrin repeats in their carboxyl termini (p105, p98), and those without such repeats that do not require processing (p65, c-Rel, RelB, and Dorsal). We demonstrate that the p105 and p98 precursors share functional properties with the I kappa B proteins, which also contain SWI6/ankyrin repeats. Both p105 and p98 were found to form stable… CONTINUE READING