p-maleimidophenyl isocyanate: a novel heterobifunctional linker for hydroxyl to thiol coupling.

@article{Annunziato1993pmaleimidophenylIA,
  title={p-maleimidophenyl isocyanate: a novel heterobifunctional linker for hydroxyl to thiol coupling.},
  author={Mauro Annunziato and Urjeet Patel and Manisha K Ranade and Paul Palumbo},
  journal={Bioconjugate chemistry},
  year={1993},
  volume={4 3},
  pages={212-8}
}
p-Maleimidophenyl isocyanate (PMPI, 1) is a heterobifunctional cross-linking agent useful for thiol to hydroxyl coupling. Several maleimide-activated compounds were prepared and characterized and then shown to be reactive with thiol-containing proteins. Examples include activation of vitamin B12, digoxigenin, digitoxigenin, estradiol, progesterone, and some serine-containing peptides. 

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