p-chlorophenylalanine attenuates the pituitary-adrenocortical response to 5-HT1A receptor agonists in mice.

@article{Matsuda1990pchlorophenylalanineAT,
  title={p-chlorophenylalanine attenuates the pituitary-adrenocortical response to 5-HT1A receptor agonists in mice.},
  author={T. Matsuda and T. Kanda and Y. Seong and A. Baba and H. Iwata},
  journal={European journal of pharmacology},
  year={1990},
  volume={181 3},
  pages={
          295-7
        }
}
The i.p. injection of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) caused hypothermia and increased the concentrations of serum corticosterone and plasma ACTH in mice. The effects of 8-OH-DPAT at a dose of 2 mg/kg but not of 0.2 mg/kg on the hormone levels were attenuated by pretreatment with p-chlorophenylalanine (pCPA) which depleted brain 5-HT by about 70%; the hypothermic effect of 8-OH-DPAT was, however, not prevented. Similar results were obtained with another 5-HT1A agonist, 1-[3… Expand
Corticosterone selectively attenuates 8-OH-DPAT-mediated hypothermia in mice.
Effects of tryptamine on plasma glucagon levels in mice
Effect of isolation on behavioural models involving serotonergic 5-HT2 and 5-HT1a receptors
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