p-Terphenyl curtisian E inhibits in vitro platelet aggregation via cAMP elevation and VASP phosphorylation.

  title={p-Terphenyl curtisian E inhibits in vitro platelet aggregation via cAMP elevation and VASP phosphorylation.},
  author={S. M. Kamruzzaman and Taddesse Yayeh and Hyun Dong Ji and Ji Young Park and Young-Sam Kwon and In-Kyoung Lee and Suk Kim and Seung Hyun Oh and Sung Dae Kim and Seong-Soo Roh and Bong-Sik Yun and Man Hee Rhee},
  journal={Vascular pharmacology},
  volume={59 3-4},

Antithrombotic activities of ferulic acid via intracellular cyclic nucleotide signaling.

Effect of Cordycepin-Enriched WIB801C from Cordyceps militaris Suppressing Fibrinogen Binding to Glycoprotein IIb/IIIa

The results strongly indicate that CE-WIB801C and cordycepin may have preventive or therapeutic potential for platelet aggregation-mediated diseases, such as thrombosis, myocardial infarction, atherosclerosis, and ischemic cerebrovascular disease.

Antiplatelet properties of natural products.

p-Terphenyl glucosides from the culture broth of Phlebiopsis castanea.

A new p-terphenyl derivative, hydroxystrepantibin D (1), was isolated along with two known p-terphenyls (2 and 3) from the culture broth of Phlebiopsis castanea. These compounds were isolated using

Non-peptide secondary metabolites from poisonous mushrooms: overview of chemistry, bioactivity, and biosynthesis.

The structures and biological activities of secondary metabolites identified from poisonous mushrooms are summarized and an overview of the current information on these metabolites is provided, focusing on their chemistry, bioactivity, and biosynthesis.



Antiplatelet Activity of Phellinus baummii Methanol Extract is Mediated by Cyclic AMP Elevation and Inhibition of Collagen‐activated Integrin‐αIIbβ3 and MAP Kinase

The observed PBME antiplatelet activity may be mediated by activation of cyclic AMP and inhibition of ERK2 and JNK1 phosphorylations, and suggest that PBME may have therapeutic potential for the treatment of cardiovascular diseases that involve aberrant platelet function.

A noble function of BAY 11-7082: Inhibition of platelet aggregation mediated by an elevated cAMP-induced VASP, and decreased ERK2/JNK1 phosphorylations.

Phellinus baumii ethyl acetate extract inhibits lipopolysaccharide-induced iNOS, COX-2, and proinflammatory cytokine expression in RAW264.7 cells

This study suggests that P. baumii might exhibit anti-inflammatory properties by downregulating proinflammatory mediators and attenuated the mRNA expression levels of proinflammatory cytokines in a concentration-dependent fashion.

Nitrolinoleate Inhibits Platelet Activation by Attenuating Calcium Mobilization and Inducing Phosphorylation of Vasodilator-stimulated Phosphoprotein through Elevation of cAMP*

The platelet inhibitory actions of LNO2 indicate that nitration reactions that occur following NO generation in an oxidizing environment can alter the activity of lipids and lend insight into mechanisms by which NO-derived species may modulate the progression of vascular injury.

P2X1-mediated ERK2 Activation Amplifies the Collagen-induced Platelet Secretion by Enhancing Myosin Light Chain Kinase Activation*

It is concluded that at low doses of collagen, glycoprotein VI activation leads to early protein kinase C- and MLC kinase-dependent degranulation and aggregation, and the P2X1-ERK2-MLC axis contributes to collagen-induced platelet activation by enhancing platelet de granulation.

A Phosphoinositide 3-Kinase-AKT-Nitric Oxide-cGMP Signaling Pathway in Stimulating Platelet Secretion and Aggregation*

This study delineates a novel platelet activation pathway involving sequential activation of PI3K, Akt, nitric-oxide synthase 3, sGC, and cGMP-dependent protein kinase and indicates that the NO-cGMP pathway is an important downstream mechanism mediatingPI3K and Akt signals leading to platelet secretion and aggregation.

Phosphoinositide 3-kinases and the regulation of platelet function.

There is evidence for an important role for PI 3-kinases in regulating a broad range of functional platelet responses, including primary platelet adhesion, cytoskeletal remodelling and platelet aggregation.

Total Saponin from Korean Red Ginseng Inhibits Thromboxane A2 Production Associated Microsomal Enzyme Activity in Platelets

The results demonstrate TSKRG is a beneficial traditional oriental medicine in platelet-mediated thrombotic diseases via suppression of COX-1 and TXAS to inhibit production of TXA2.

Platelet JNK1 is involved in secretion and thrombus formation.

In vitro studies carried out in platelet aggregation conditions demonstrated that, at low doses of agonists, platelet secretion was impaired in JNK1(-/-) platelets, leading to altered integrin alphaIIbbeta3 activation and reduced platelets aggregation, via a mechanism involving protein kinase C.

Growth arrest-specific gene 6 (gas6) and vascular hemostasis.

The role of gas6 in innate immunity, atherosclerosis, thrombosis, and cancer-related events, and the mechanism in thrombus occurrence is focused on.