p-Nitrophenol hydroxylation. A microsomal oxidation which is highly inducible by ethanol.

@article{Reinke1985pNitrophenolHA,
  title={p-Nitrophenol hydroxylation. A microsomal oxidation which is highly inducible by ethanol.},
  author={Lester A. Reinke and Maria Moyer},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1985},
  volume={13 5},
  pages={
          548-52
        }
}
p-Nitrophenol is widely employed as a substrate for the study of the glucuronide and sulfate conjugation pathways. However, in perfused livers from ethanol-treated rats, p-nitrophenol was rapidly metabolized to 4-nitrocatechol. The 4-nitrocatechol formed competed with p-nitrophenol for conjugation with glucuronic acid and sulfate, and interfered with the direct spectral measurement of p-nitrophenol. In isolated microsomes, rates of p-nitrophenol hydroxylation were increased 6-fold after chronic… CONTINUE READING

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