p-FAK-Tyr(397) regulates spermatid adhesion in the rat testis via its effects on F-actin organization at the ectoplasmic specialization.

@article{Wan2013pFAKTyr397RS,
  title={p-FAK-Tyr(397) regulates spermatid adhesion in the rat testis via its effects on F-actin organization at the ectoplasmic specialization.},
  author={Hin-ting Wan and Dolores Dorothy Mruk and Stephen Y T Li and Keng Kio Mok and W. M. Peter Lee and Chris Kong Chu Wong and Chung-ying Cheng},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2013},
  volume={305 6},
  pages={
          E687-99
        }
}
During spermatogenesis, the molecular mechanism that confers spermatid adhesion to the Sertoli cell at the apical ectoplasmic specialization (apical ES), a testis-specific F-actin-rich adherens junction, in the rat testis remains elusive. Herein, the activated form of focal adhesion kinase (FAK), p-FAK-Tyr(397), a component of the apical ES that was expressed predominantly and stage specifically in stage VII-early stage VIII tubules, was found to be a crucial apical ES regulator. Using an FAK… CONTINUE READING

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