p-Coumaric acid, a common dietary phenol, inhibits platelet activity in vitro and in vivo

@article{Luceri2007pCoumaricAA,
  title={p-Coumaric acid, a common dietary phenol, inhibits platelet activity in vitro and in vivo},
  author={Cristina Luceri and Lucia Giannini and Maura Lodovici and Emilia Antonucci and Rosanna Abbate and Emanuela Masini and Piero Dolara},
  journal={British Journal of Nutrition},
  year={2007},
  volume={97},
  pages={458 - 463}
}
p-Coumaric acid (3-(4-hydroxyphenyl)-2-propenoic acid; 4CA), is a ubiquitous plant metabolite with antioxidant and anti-inflammatory properties. The antiplatelet activity of this compound was analysed both ex vivo and in vitro. 4-CA, administered to rabbits for 2 weeks at the dose of 5 mg/kg, mixed with food, inhibited ADP-induced platelet aggregation without affecting blood coagulation. This effect was associated with a marked increase in plasma antioxidant activity, measured as ferric… 
p-Coumaric acid and its conjugates: dietary sources, pharmacokinetic properties and biological activities.
TLDR
Cumulative evidence from multiple studies indicates that conjugation of p-coumaric acid greatly strengthens its biological activities; however, the high biological activity but low absorption of its conjugates remains a puzzle.
Ameliorative effect of p-coumaric acid, a common dietary phenol, on adjuvant-induced arthritis in rats
TLDR
The present study clearly demonstrates the anti-inflammatory potential of the p-coumaric acid against adjuvant-induced arthritis in rats.
The influence of microbial isoflavonoid specific metabolites on platelets and transition metals iron and copper.
The colonic metabolites dihydrocaffeic acid and dihydroferulic acid are more effective inhibitors of in vitro platelet activation than their phenolic precursors.
TLDR
The colonic metabolites had stronger inhibitory effects on P-selectin expression than their phenolic precursors, suggesting an increase in the efficacy to modulate platelet activation with the metabolism of the phenolic compounds.
p-Coumaric acid in cereals: presence, antioxidant and antimicrobial effects
Summary Coumaric acid is a hydroxy derivative of cinnamic acid and naturally occurs in three isomers (ortho-, meta- and para-); p-coumaric acid is one of the most commonly occurring isomer in
Antiperoxidative potential of p-coumaric acid, a common dietary phenol, in adjuvant-induced arthritis in rats.
TLDR
Soft swelling, bone erosion, and joint space narrowing noticed in arthritic rats were found to be mitigated in p-coumaric acid-treated arthrite rats, indicating the antiperoxidative potential of p-Coumarics acid against adjuvant-induced arthritis in rats.
Dietary component p-coumaric acid suppresses monosodium urate crystal-induced inflammation in rats
TLDR
The potential anti-inflammatory effect of p-Coumaric acid against monosodium urate crystal-induced inflammation in rats is revealed, as evidenced by the histopathology of the ankle joints.
Immunomodulatory and Anti-inflammatory Effect of p-Coumaric Acid, a Common Dietary Polyphenol on Experimental Inflammation in Rats
TLDR
The results show that p-coumaric acid could be considered a potential immunosuppressive agent in treating autoimmune inflammatory diseases like rheumatoid arthritis.
Scavenging Properties of Plant-Derived Natural Biomolecule Para-Coumaric Acid in the Prevention of Oxidative Stress-Induced Diseases
TLDR
Para-coumaric acid can ameliorate the harmful effects associated with oxidative stress in the reproductive system, also by inhibiting enzymes linked with erectile function.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 53 REFERENCES
Antiplatelet activity of synthetic and natural resveratrol in red wine.
TLDR
The results suggest that the antiaggregating activity of resveratrol is related to its concentration in wine.
Plant phenolic 4-coumaric acid protects against intestinal inflammation in rats.
TLDR
It was found that treatment with 4CA prior to DSS-induced inflammation reduced oxidative DNA damage, COX-2 over-expression, and cyclooxygenase-2 expression and activity and restored SOD-2 gene expression to control levels.
Effect of 4-coumaric and 3,4-dihydroxybenzoic acid on oxidative DNA damage in rat colonic mucosa.
TLDR
The data suggest that 4-coumaric acid acts as an antioxidant in the colonic mucosa in vivo, relative to vitamin E.
Biochemical and pharmacological characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases.
TLDR
A model of human prostaglandin endoperoxide synthase-2 expression allowing the assessment of pharmacological inhibition in vitro and ex vivo was characterized and cyclooxygenase activity increased in parallel with the mass of a monocyte protein doublet analyzed by Western blot using antibodies directed against the carboxyl-terminal portion of human PGHS-2.
Intestinal absorption of p-coumaric and gallic acids in rats after oral administration.
TLDR
This is the first demonstration that absorption efficiency of CA is much higher than that of GA in vivo, and these findings are in good agreement with the results obtained in vitro using a Caco-2 cell system.
Effect of natural phenolic acids on DNA oxidation in vitro.
The flavonoids quercetin and catechin synergistically inhibit platelet function by antagonizing the intracellular production of hydrogen peroxide.
TLDR
Data indicate that flavonoids inhibit platelet function by blunting hydrogen peroxide production and, in turn, phospholipase C activation and suggest that the synergism among flavonoid could contribute to an understanding of the relation between the moderate consumption of red wine and the decreased risk of cardiovascular disease.
Grape seed and grape skin extracts elicit a greater antiplatelet effect when used in combination than when used individually in dogs and humans.
TLDR
The results suggest that the components of GSD and GSK, when present in combination as in red wine, grape juice or in a commercial preparation containing both extracts, exhibit a greater antiplatelet effect than when present individually.
Effects of catechins on human blood platelet aggregation and lipid peroxidation
TLDR
It is suggested that catechins protect platelets from peroxidative stress and their aggregation and malondialdehyde production of MDA of the platelets treated with catechin or epicatechin after stimulation by arachidonic acid was observed.
...
1
2
3
4
5
...