p-Chlorophenylalanine-induced alterations in the behavioral effects of 5-hydroxytryptophan

@article{Boggan1973pChlorophenylalanineinducedAI,
  title={p-Chlorophenylalanine-induced alterations in the behavioral effects of 5-hydroxytryptophan},
  author={William O. Boggan and Daniel X. Freedman and James B. Appel},
  journal={Psychopharmacologia},
  year={1973},
  volume={33},
  pages={293-298}
}
Pretreatment of rats with p-chlorophenylalanine methyl ester (PCPA-ME) causes a normally non-effective dose of 5-hydroxytryptophan (5-HTP) to disrupt bar-pressing at times when serotonin (5-HT) concentration is depleted. There does not appear to be any correlation between the initial, behaviorally-distruptive effects of PCPA-ME and the action of this compound on 5-HT biosynthesis. 

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