p-Chloroamphetamine (PCA), 3,4-methylenedioxymethamphetamine (MDMA) andd-fenfluramine pretreatment attenuatesd-fenfluramine-evoked release of 5-HT in vivo

@article{Series2005pChloroamphetamine3,
  title={p-Chloroamphetamine (PCA), 3,4-methylenedioxymethamphetamine (MDMA) andd-fenfluramine pretreatment attenuatesd-fenfluramine-evoked release of 5-HT in vivo},
  author={H G Series and Philip J. Cowen and Trevor Sharp},
  journal={Psychopharmacology},
  year={2005},
  volume={116},
  pages={508-514}
}
  • H G Series, Philip J. Cowen, Trevor Sharp
  • Published in Psychopharmacology 2005
  • Psychology, Medicine
  • Previous work has suggested that repeated treatment with substituted amphetamines including PCA, MDMA andd-fenfluramine produces a persistent neurodegeneration which is relatively selective for the fine serotoninergic terminals arising from the dorsal raphe nucleus. The aim of the present study was to investigate whether the acute releasing effect ofd-fenfluramine might also be sensitive to lesions produced by PCA, MDMA andd-fenfluramine itself. Basal and 5-HT release evoked byd-fenfluramine or… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 36 REFERENCES

    Effect of the 5-HT neurotoxin p-chloroamphetamine on rat hippocampal 5-HT release evoked by electrical stimulation of the dorsal and median raphe nuclei

    • R McQuade, PJ Cowen, T Sharp
    • Br J Pharmacol
    • 1994

    Evidence that d-fenfluramine releases 5-HT selectively from terminals of dorsal raphe neurons

    • HG Series, T Sharp, DG Grahame-Smith
    • Br J Pharmacol
    • 1993
    VIEW 1 EXCERPT

    Decreased 5-HT-mediated prolactin release in major depression.

    Dexfen - fluramine and neurotoxicity

    • G Baumgarten, S Garattini, S Lorens, R Wurtman
    • Lancet
    • 1992