p-Aminobenzamidine, an acrosin inhibitor, inhibits mouse sperm penetration of the zona pellucida but not the acrosome reaction.

@article{Fraser1982pAminobenzamidineAA,
  title={p-Aminobenzamidine, an acrosin inhibitor, inhibits mouse sperm penetration of the zona pellucida but not the acrosome reaction.},
  author={Lynn R. Fraser},
  journal={Journal of reproduction and fertility},
  year={1982},
  volume={65 1},
  pages={185-94}
}
The effect of p-aminobenzamidine (pAB), an inhibitor of mouse sperm acrosin, on mouse sperm capacitation, motility, acrosome loss and fertility in vitro was examined using zona-intact and zona-free eggs. With intact eggs, concentrations of pAB ranging from 0.1 to 1.0 mM in the sperm preincubation medium effectively inhibited fertilization (13-0%, respectively), but these same suspensions (10(6) cells/ml) showed high rates of fertilization with zona-free eggs (100-95.3%); with the lower… CONTINUE READING

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With intact eggs , concentrations of pAB ranging from 0.1 to 1.0 mM in the sperm preincubation medium effectively inhibited fertilization ( 13 - 0% , respectively ) , but these same suspensions ( 10(6 ) cells / ml ) showed high rates of fertilization with zona - free eggs ( 100 - 95.3% ) ; with the lower concentration of 10(5 ) cells / ml , fertilization rates of zona - free eggs decreased with increasing concentrations of pAB ( 100 - 55% ) .
With intact eggs , concentrations of pAB ranging from 0.1 to 1.0 mM in the sperm preincubation medium effectively inhibited fertilization ( 13 - 0% , respectively ) , but these same suspensions ( 10(6 ) cells / ml ) showed high rates of fertilization with zona - free eggs ( 100 - 95.3% ) ; with the lower concentration of 10(5 ) cells / ml , fertilization rates of zona - free eggs decreased with increasing concentrations of pAB ( 100 - 55% ) .
With intact eggs , concentrations of pAB ranging from 0.1 to 1.0 mM in the sperm preincubation medium effectively inhibited fertilization ( 13 - 0% , respectively ) , but these same suspensions ( 10(6 ) cells / ml ) showed high rates of fertilization with zona - free eggs ( 100 - 95.3% ) ; with the lower concentration of 10(5 ) cells / ml , fertilization rates of zona - free eggs decreased with increasing concentrations of pAB ( 100 - 55% ) .
With intact eggs , concentrations of pAB ranging from 0.1 to 1.0 mM in the sperm preincubation medium effectively inhibited fertilization ( 13 - 0% , respectively ) , but these same suspensions ( 10(6 ) cells / ml ) showed high rates of fertilization with zona - free eggs ( 100 - 95.3% ) ; with the lower concentration of 10(5 ) cells / ml , fertilization rates of zona - free eggs decreased with increasing concentrations of pAB ( 100 - 55% ) .
With intact eggs , concentrations of pAB ranging from 0.1 to 1.0 mM in the sperm preincubation medium effectively inhibited fertilization ( 13 - 0% , respectively ) , but these same suspensions ( 10(6 ) cells / ml ) showed high rates of fertilization with zona - free eggs ( 100 - 95.3% ) ; with the lower concentration of 10(5 ) cells / ml , fertilization rates of zona - free eggs decreased with increasing concentrations of pAB ( 100 - 55% ) .
With intact eggs , concentrations of pAB ranging from 0.1 to 1.0 mM in the sperm preincubation medium effectively inhibited fertilization ( 13 - 0% , respectively ) , but these same suspensions ( 10(6 ) cells / ml ) showed high rates of fertilization with zona - free eggs ( 100 - 95.3% ) ; with the lower concentration of 10(5 ) cells / ml , fertilization rates of zona - free eggs decreased with increasing concentrations of pAB ( 100 - 55% ) .
OvumNo subtypesperm cell
The effect of p - aminobenzamidine ( pAB ) , an inhibitor of mouse sperm acrosin , on mouse sperm capacitation , motility , acrosome loss and fertility in vitro was examined using zona - intact and zona - free eggs .
The effect of p - aminobenzamidine ( pAB ) , an inhibitor of mouse sperm acrosin , on mouse sperm capacitation , motility , acrosome loss and fertility in vitro was examined using zona - intact and zona - free eggs .
sperm cellNo subtypeOvum
The effect of p - aminobenzamidine ( pAB ) , an inhibitor of mouse sperm acrosin , on mouse sperm capacitation , motility , acrosome loss and fertility in vitro was examined using zona - intact and zona - free eggs .
The effect of p - aminobenzamidine ( pAB ) , an inhibitor of mouse sperm acrosin , on mouse sperm capacitation , motility , acrosome loss and fertility in vitro was examined using zona - intact and zona - free eggs .
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