p 62 / SQSTM 1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

@inproceedings{Bjrky2005p6,
  title={p 62 / SQSTM 1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death},
  author={Geir Bj\ork\oy and Trond Lamark and Andreas Brech and Heidi Outzen and Maria Perander and Aud \Overvatn and Harald Stenmark and Terje Johansen},
  year={2005}
}
utophagic degradation of ubiquitinated protein aggregates is important for cell survival, but it is not known how the autophagic machinery recognizes such aggregates. In this study, we report that polymerization of the polyubiquitin-binding protein p62/ SQSTM1 yields protein bodies that either reside free in the cytosol and nucleus or occur within autophagosomes and lysosomal structures. Inhibition of autophagy led to an increase in the size and number of p62 bodies and p62 protein levels. The… CONTINUE READING

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