p 53 : Structure , Function and Therapeutic Applications

  title={p 53 : Structure , Function and Therapeutic Applications},
  author={Ling Bai and Wei-Guo Zhu},
Since the p53 tumor suppressor gene has been found to be mutated in more than 50% of human cancers, it has attracted the interest of numerous researchers. The capacity of p53 for multiple biological functions can be attributed to its ability to act as a sequence-specific transcription factor to regulate expression of over one hundred different targets, and thus to modulate various cellular processes including apoptosis, cell cycle arrest and DNA repair. The p53 protein with its unique Cand N… CONTINUE READING
68 Citations
206 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 68 extracted citations


Publications referenced by this paper.
Showing 1-10 of 206 references

Similar Papers

Loading similar papers…