p 38 protects human melanoma cells from UV-induced apoptosis through down-regulation of NFk B activity and Fas expression

Abstract

Identifying mechanisms that underlie the resistance of human melanoma to radiation and chemotherapy is expected to assist in developing new strategies for the treatment of this tumor type. We recently demonstrated that through up-regulation of TNFa, ATF2 increases the resistance of late stage melanoma cells to apoptosis induced by UV-irradiation. In… (More)

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