p 300 / CBP-mediated p 53 acetylation is commonly induced by p 53-activating agents and inhibited by MDM 2

@inproceedings{Ito2001p3,
  title={p 300 / CBP-mediated p 53 acetylation is commonly induced by p 53-activating agents and inhibited by MDM 2},
  author={Akihiro Ito and Chun-Hsiang Lai and Xuan Jen Zhao and Shin'ichi Saito and M H Hamilton and Ettore Appella and Tso-pang Yao},
  year={2001}
}
The tumor suppressor p53 is activated in response to many types of cellular and environmental insults via mechanisms involving post-translational modi®cation. Here we demonstrate that, unlike phosphorylation, p53 invariably undergoes acetylation in cells exposed to a variety of stress-inducing agents including hypoxia, anti-metabolites, nuclear export inhibitor and actinomycin D treatment. In vivo, p53 acetylation is mediated by the p300 and CBP acetyltransferases. Overexpression of either p300… CONTINUE READING

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Acidic domain is indispensable for MDM2 to negatively regulate the acetylation of p53.

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