p 12 CDK 2-AP 1 Gene Therapy Strategy Inhibits Tumor Growth in an In vivo MouseModel of Head and Neck Cancer

@inproceedings{Figueiredo2005p1C,
  title={p 12 CDK 2-AP 1 Gene Therapy Strategy Inhibits Tumor Growth in an In vivo MouseModel of Head and Neck Cancer},
  author={Marxa L Figueiredo and Yong Kim and Maie St. John and David Wong},
  year={2005}
}
Purpose:To test the potential of p12 (p12), a cell cycle regulator and cyclin-dependent kinase-2-associating protein commonly down-regulated in head and neck squamous cell carcinoma (f70%), as a gene therapy in inhibiting head and neck squamous cell carcinoma growth in vivo. Experimental Design:We addressed the effect of p12 expression on tumor growth by using a well-established squamous cell carcinomaVII/SF floor of mouth xenograft mouse model. The effect of therapy on tumor growth was… CONTINUE READING

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