p‐Methylthioamphetamine and 1‐(m‐chlorophenyl)piperazine, two non‐neurotoxic 5‐HT releasers in vivo, differ from neurotoxic amphetamine derivatives in their mode of action at 5‐HT nerve endings in vitro

@article{Gobbi2002pMethylthioamphetamineA1,
  title={p‐Methylthioamphetamine and 1‐(m‐chlorophenyl)piperazine, two non‐neurotoxic 5‐HT releasers in vivo, differ from neurotoxic amphetamine derivatives in their mode of action at 5‐HT nerve endings in vitro},
  author={M. Gobbi and M. Moia and L. Pirona and I. Ceglia and M. Reyes-Parada and C. Scorza and T. Mennini},
  journal={Journal of Neurochemistry},
  year={2002},
  volume={82}
}
  • M. Gobbi, M. Moia, +4 authors T. Mennini
  • Published 2002
  • Medicine, Chemistry
  • Journal of Neurochemistry
  • The mechanism underlying the serotoninergic neurotoxicity of some amphetamine derivatives, such as p‐chloroamphetamine (pCA) and 3,4‐methylenedioxymethamphetamine (MDMA), is still debated. Their main acute effect, serotonin (5‐HT) release from nerve endings, involves their interaction with 5‐HT transporters (SERTs), as substrates. Although this interaction is required for the neurotoxic effects, 5‐HT release alone may not be sufficient to induce long‐term 5‐HT deficits. Some non‐neurotoxic… CONTINUE READING
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