p‐Methoxyamphetamine, a potent reversible inhibitor of type‐A monoamine oxidase in vitro and in vivo

@article{Green1980pMethoxyamphetamineAP,
  title={p‐Methoxyamphetamine, a potent reversible inhibitor of type‐A monoamine oxidase in vitro and in vivo},
  author={Alysia L. Green and Mayyada A. S. el Hait},
  journal={Journal of Pharmacy and Pharmacology},
  year={1980},
  volume={32}
}
  • A. Green, M. Hait
  • Published 1980
  • Medicine, Chemistry
  • Journal of Pharmacy and Pharmacology
p‐Methoxyamphetamine is over 20 times as potent as (+)‐amphetamine as an inhibitor of 5‐HT oxidation by monoamine oxidase in mouse brain in vitro, with a Ki value of 0·22 μM. It is highly selective towards A‐type monoamine oxidase and possesses only weak activity against the B‐type enzyme (Ki value about 500 μM with benzylamine as substrate and solubilized rat liver mitochondria as enzyme source). It is 10 times more active than (+)‐amphetamine in protecting mouse brain monoamine oxidase from… Expand
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Inhibition of mouse brain monoamine oxidase by (+)‐amphetamine in vivo
  • A. Green, M. Hait
  • Medicine, Chemistry
  • The Journal of pharmacy and pharmacology
  • 1978
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