p,p'-Methoxyl-diphenyl diselenide protects against amyloid-β induced cytotoxicity in vitro and improves memory deficits in vivo.

Abstract

Behavioral evidence suggests that the organoselenium compound p,p'-methoxyl-diphenyl diselenide [(MeOPhSe)2] ameliorates memory and learning performance in rodents. Here, we investigated the molecular mechanism of (MeOPhSe)2 neuroprotection in cortical neurons exposed to amyloid-β (Aβ) peptide as well as in Aβ-infused mice. For this purpose, primary… (More)
DOI: 10.1016/j.bbr.2013.03.034

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Cite this paper

@article{Pinton2013ppMethoxyldiphenylDP, title={p,p'-Methoxyl-diphenyl diselenide protects against amyloid-β induced cytotoxicity in vitro and improves memory deficits in vivo.}, author={Simone Pinton and Ana Cristina Guerra Souza and Marcel H M Sari and Rita Mira Ramalho and Cec{\'i}lia M. P. Rodrigues and Cristina Wayne Nogueira}, journal={Behavioural brain research}, year={2013}, volume={247}, pages={241-7} }