oprM as a new target for reversion of multidrug resistance in Pseudomonas aeruginosa by antisense phosphorothioate oligodeoxynucleotides.

@article{Wang2010oprMAA,
  title={oprM as a new target for reversion of multidrug resistance in Pseudomonas aeruginosa by antisense phosphorothioate oligodeoxynucleotides.},
  author={Hui Wang and Jingru Meng and Min Jia and Xue shan Ma and Gonghao He and Jichen Yu and Rutao Wang and Hui Bai and Zheng Hou and Xiaoxing Luo},
  journal={FEMS immunology and medical microbiology},
  year={2010},
  volume={60 3},
  pages={275-82}
}
Multidrug-resistant Pseudomonas aeruginosa (MDR-PA) is one of the leading Gram-negative organisms associated with nosocomial infections. The increasing frequency of MDR-PA has represented a huge challenge in conventional antibacterial therapy. The loss of effectiveness of commonly used antibiotics calls for the immediate need to develop an alternative strategy for combating MDR-PA infections. The multiantibiotic resistance of MDR-PA is largely attributable to the production of multidrug efflux… CONTINUE READING

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