[op.lb03.09] the Acute Effect of the Specific Creatine Kinase Inhibitor Beta- Gpa in Healthy Man (abc-trial): a Randomized Placebo and Active Controlled First-in-human Trial.

Abstract

OBJECTIVE There is increasing evidence that the ATP generating enzyme creatine kinase (CK) is involved in hypertension. The enzyme is central to the regeneration of ATP by using creatine phosphate and ADP, thereby forming creatine and ATP. We recently showed that beta-guanidinopropionic acid (GPA), a creatine analogue and competitive CK inhibitor… (More)
DOI: 10.1097/01.hjh.0000491631.82602.db

Topics

Cite this paper

@article{Karamat2016oplb0309TA, title={[op.lb03.09] the Acute Effect of the Specific Creatine Kinase Inhibitor Beta- Gpa in Healthy Man (abc-trial): a Randomized Placebo and Active Controlled First-in-human Trial.}, author={Fares A Karamat and Deborah L Horjus and Yentl C L Haan and Lisa van der Woude and Marianne C. L. Schaap and Inge Oudman and Gert A. van Montfrans and Rienk Nieuwland and Joseph F. Clark and Augueste Sturk and Lizzy M Brewster}, journal={Journal of hypertension}, year={2016}, volume={34 Suppl 2}, pages={e113-4} }