omega-Iodophenyl fatty acids: a convenient method of radioiodination.

@article{Otto1986omegaIodophenylFA,
  title={omega-Iodophenyl fatty acids: a convenient method of radioiodination.},
  author={Charlotte A. Otto and H T Lee and Thomas J. Mangner and Donald M. Wieland},
  journal={International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes},
  year={1986},
  volume={37 3},
  pages={
          205-10
        }
}
  • C. OttoH. Lee D. Wieland
  • Published 1986
  • Biology
  • International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes
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7 Citations
Methods Citations
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7 Citations

High specific activity 15-(p-[123I]iodophenyl)pentadecanoic acid.

Dry state preparation of radioiodine labeled meta-iodobenzylguanidine

Radioiodination of meta-iodobenzylguanidine (MIBG) by the isotopic exchange technique in the dry state has been performed. Benzoic acid, pivalic acid and acetamide have been used as molten protic…

Simplified solid-state labeling of [123I]m-iodobenzylguanidine

Evaluation of the reaction parameters and thermodynamics of the iodide-exchange preparation of radioiodinated 15-(p-iodophenyl) pentadecanoic acid by both solid phase and solution methods

Two isotopic exchange procedures are described for the labelling of 15-(p-iodophenyl) pentadecanoic acid with radioiodine in the presence of ammonium sulphate and cuprous chloride as catalysts The…

Syntheses and Uses of Isotopically Labelled Organic Halides

In isotopically labelled organic halides - synthesis and uses, isotope effect studies with organic halide studies, and organic compounds labelled with astatine-211 synthesis are reviewed.

Spezielle Syntheseverfahren mit kurzlebigen Radionukliden und Qualitätskontrolle

Kurzlebige Zyklotron-produzierte Radionuklide gewinnen in der modernen nuklearmedizinischen Funktionsdiagnostik zunehmend an Bedeutung. Das ideale Radionuklid fur in-vivo Anwendungen sollte moglichst…

NMDA receptor channels: labeling of MK-801 with iodine-125 and fluorine-18.

  • D. WielandM. Kilbourn A. Young
  • Chemistry, Biology
    International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes
  • 1988

References

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Solid-phase exchange radioiodination of aryl iodides. Facilitation by ammonium sulfate

Preliminary experiments suggest that, with this technique interhalogen exchange of aryl bromides with radioiodine is a feasible approach to the preparation of no-carrier-added aryL radioiodides.

Synthesis of 15-(p-iodophenyl)-6-tellurapentadecanoic acid: a new myocardial imaging agent

Hydrolysis produced methyl-15-(p-iodophenyl)-6-tellurapentadecanoate, which can be used in the synthesis of other fatty acid analogues and showed prolonged myocardial retention in rats with little in vivo deiodination.

A condition variation study for radioiodination via triazene intermediates

Pyrrolidyl triazenes prepared by interception of the diazonium transient in the Sandmeyer reaction of amines can serve as useful intermediates in the iodination and radioiodination of aryl rings.…

Simple labeling of ω-phenylfatty acids by iodine isotope exchange

Iodination methods for routine preparation of 17-123I-heptadecanoic acid and 15-(123I-phenyl)-pentadecanoic acid

Different labeling approaches were evaluated to increase the yield of the entrire procedure and each laboratory is able to select the method appropriate for their individual demands and possibilities.

15-(p[75Br]bromophenyl)pentadecanoic acid: pharmacokinetics and potential as heart agent.

While the uptake of BPPA in the heart muscle is as fast and efficient as that of aliphatic omega-halofatty acids, its elimination is delayed, owing mainly to an inhibited beta oxidation and the formation of lipophilic catabolites.

Radioiodinated fatty acids for myocardial imagine: effects on chain length.

The cellular fate of the fatty acid changes form that of beta -oxidation for n less than or equal to 15 to predominantly triglyceride storage for n = 18 and 21, as shown by analysis of rat heart homogenates by thin layer chromatography at two time intervals.

Preparation and purification of ω-(p-123I-Iodophenyl)-pentadecanoic acid

Synthesis and evaluation of radioiodinated terminal p-iodophenyl-substituted alpha- and beta-methyl-branched fatty acids.

Results suggest that the mechanism of myocardial retention results from steric or chemical inhibition of the metabolism of these fatty acids by the presence of the methyl group.

Development of 15-(p-123I-phenyl)-pentadecanoic acid for in-vivo diagnosis of the myocardium

The results found to agree with the expectations based on the principal metabolic path of phenylfatty acids, 15-(123I-phenyl)-pentadecanoic acid (IPPA) could be brought into clinical application with success.